~Activities~

▶︎(Furumoto_B6) HDAC6 inhibition mitigates renal fibrosis by suppressing TGF-b and EGFR signaling pathways in obstructive nephropathy. Am J Physiol Renal Physiol 2020, doi. 10.1152/ajprenal.00261.2020. + Selective inhibition of class IIa HDACs alleviates renal fibrosis. FASEB J 2019, doi: 10.1096/fj.201801067RR.
▶︎(Norimine_B6) A tumor-derived type III collagen-rich ECM niche regulates tumor cell dormancy. Nat Cancer 2022, doi: 10.1038/ s43018-021-00291-9. + Prognostic and therapeutic implications of tumor-restrictive type III collagen in the breast cancer microenvironment. NPJ Breast Cancer 2024, doi: 10.1038/s41523-024-00690-y.
▶︎(Ohta_B6) Long non-coding RNA lnc-CHAF1B-3 promotes renal interstitial fibrosis by regulating EMT-related genes in renal proximal tubular cells. Mol Ther Nucleic Acids 2023, doi: 10.1016/j.omtn.2022.12.011. + LncRNA Linc00968 accelerates the proliferation and fibrosis of diabetic nephropathy by epigenetically repressing p21 via recruiting EZH2. Biochem Biophys Res Commun 2018, doi: 10.1016/j.bbrc. 2018.08.048.
▶︎(Imamoto_B6) Ablation of ferroptosis regulator GPX4 in forebrain neurons promotes cognitive imparemet and nerodegeneration. Redox Biol 2017, doi: doi: 10.1016/j.redox.2017.01.021. + Fostered Nrf2 expression antagonizes iron overload and glutathione depletion to promote resistance of neuron-like cells to ferroptosis. Toxicol Appl Parmacol 2020, doi: 10.1016/j.taap.2020.115241. + A CoQ10 analog ameliorates cognitive impairment and early brain injury after subarachnoid hemorrhage by regulating ferroptosis and neuroinflammation. Redox Biol 2025, doi: 10.1016/j.redox.2025.103684.
⚫︎⚫︎【PROGRESS REPORT_B6】⚫︎⚫︎
▶︎(Sumide_B5) Ginseng extract improves synaptic resiliency: A key factor for healthy cognitive aging. Alzheimers Dement 2025, doi: 10. 1002/alz. 70818. + Neutral pH-selective inhibition of cytosolic cathepsin B: A novel drug targeting strategy for traumatic brain injury and alzheimer's disease (Review). ACS Chem Biol 2025, doi: 10.1021/acschembio.5c00463.
▶︎(Kuroda_B5) Rac1 suppression by the fcal adhesion protein GIT arfGAP2 and podocyte protection. J Am Soc Nephrol 2025, doi: 10. 1681/ASN. 0000000614. + Rac1 activation in podocytes induces the spectrum of nephrotic syndrome. Kidney Int 2017, doi: 10.1016/j.kint.2017.03. 010. 

▶︎Targeting HIF-1alpha abrogates PD-L1-mediated immune evasion in tumor microenvironment but promotes tolerance in normal tissues. J Clin Invest 2022. doi: 10.1172/JCI150846.
▶︎TAM-derived exosomal miR-589-3p accelerates ovarian cancer progression through BCL2L13. J Ovarian Res 2025. doi: 10.118 6/s13048-025-01618-1.​
▶︎microRNA in Extracellular Vesicles Released by Damaged Podocytes Promote Apoptosis of Renal Tubular Epithelial Cells. Cells 2020. doi: 10.3390/cells9061409.
▶︎Farrerol attenuates β-amyloid-induced oxidative stress and inflammation through Nrf2/Keap1 pathway in a microglia cell line. Biomed Pharmacother 2019. doi: 10.1016/j.biopha.2018.10.053.
​▶︎Tim-3 aggravates podocyte injury in diabetic nephropathy by promoting macrophage activation via the NF-κB/TNF-α path-way. Mol Metab 2019. doi: 10.1016/j.molmet.2019.02.007..
▶︎Breast tumor cell TACE-shed MCSF promotes pro-angiogenic macrophages through NF-kB signaling. Angiogenesis 2014. doi: 10.1007/s10456-013-9405-2.
▶︎Complement C3 enhances LPS-elicited neuroinflammation and neurodegeneration via the Mac1/NOX2 pathway. Mol Neurobiol 2023. doi: 10.1007/s12035-023-03393-w.
▶︎The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation. Nat Commun 2021. doi: 10.1038/s41467-021-22979-3, + Diminished expression of the ubiquitin-proteasome system in early treatment-naïve patients with rheumatoid arthritis and concomitant type 2 diabetes may be linked to IL-1 pathway hyper-activity; results from PEAC cohort. Artheritis Res Ther 2024. doi: 10.1186/s13075-024-03392-9.
▶︎Glioma angiogenesis is boosted by ELK3 activating the HIF-1 α /VEGF-A signaling axis. BMC Cancer 2023. doi: 10.1186/s128 85-023-11069-w, + Upregulation of HLA-II related to LAG-3+CD4+ T cell infiltration is associated with patient outcome in human glioblastoma. Cancer Sci 2024. doi: 10.1111/cas.16128. 
▶︎Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription. PNAS 2009. doi: 10.1073/pnas.0807991106, + Metformin Facilitates Amyloid-β Generation by β- and γ-Secretases via Autophagy Activation. J Alzheimers Dis 2016. doi: 10.3233/JAD-151200.
▶︎Syndecan-4/PAR-3 signaling regulates focal adhesion dynamics in mesenchymal cells. Cell Commun Signal 2020. doi:10.1186/s 12964-020-00629-3, + Syndecan-4 is a maestro of gastric cancer cell invasion and communication that underscores poor survi- val. PNAS 2023. doi: 10.1073/pnas.2214853120.

▶︎ TREM2 modulation remodels the tumor myeloid landscape enhancing anti-PD-1 immunotherapy. Cell 2020. doi: 10.1016/j.cell .2020.07. 013, + TREM2 knockdown improves the therapeutic effect of PD-1 blockade in hepatocellular carcinoma. BBRC 2022. doi:10.1016/j.bbrc. 2022.10.079, + Immune evasion through mitochondrial transfer in the tumour microenvironment. Nature 2025. doi: 10.1038/s41586-024-08 439-0, + Mitochondrial swap from cancer to immune cells thwarts anti-tumour defences. Nature 2025. doi: ***.
▶︎Tenascin-C promotes acute kidney injury to chronic kidney disease progression by impairing tubular integrity via αvβ6 integrin signaling. Kidney Int 2020. doi: 0.1016/j.kint.2020.01.026.
▶︎Hyperglycemic levels in early stage of diabetic nephropathy affect differentially renal expression of claudins-2 and -5 by oxidative stress. Life Sci 2021. doi: 10.1016/j.lfs.2020.119003.
▶︎Kaempferol-3-o-β-d-glucuronate exhibit potential anti-inflammatory effect in LPS stimulated Raw 264.7 cells and mice model. Int J Immunopharmacol 2018. doi: 10.1016/j.intimp.2018.01.041, + Antioxidant and Antineuroinflammatory Mechanisms of Kaempferol-3- O-β-d-Glucuronate on Lipopolysaccharide-Stimulated BV2 Microglial Cells through the Nrf2/HO-1 Signaling Cascade and MAPK/NF-κB Pathway. ACS Omega 2023. doi: 10.1021/acsomega.2c06916.
▶︎(V600E)BRAF Inhibition Induces Cytoprotective Autophagy through AMPK in Thyroid Cancer Cells. Int J Mol Sci 2021. doi: 10.3 390/ ijms22116033, + Notch pathway is activated by MAPK signaling and influences papillary thyroid cancer proliferation. Trasl Oncol 2013. doi: 10.1593/tlo.12442., + (V600E)BRAF promotes invasiveness of thyroid cancer cells by decreasing E-cadherin expression through a Snail-dependent mechanism. Cancer Let 2013. doi: 10.1016/j.canlet.2013.02.033.
▶︎Autophagy deficiency exacerbates acute lung injury induced by copper oxide nanoparticles. J Nanobiotechnology 2021. doi: 10.1186/s12 951-021-00909-1, + Reciprocal regulation of NRF2 by autophagy and ubiquitin-proteasome modulates vascular endothelial injury induced by copper oxide nanoparticles. J Nanobiotechnology 2022. doi: 10.1186/s12951-022-01486-7.
▶︎TREM2 haplodeficiency in mice and humans impairs the microglia barrier function leading to decreased amyloid compaction and severe axonal dystrophy. Neuron 2016. doi: 10.1016/j.neuron.2016.05.003, + TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease. Cell 2017. doi: 10.1016/j.cell.2017.07.023.
▶︎Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans. J Clin Invest 2010. doi: 10.1172/J CI43025. + PGC-1 α Protects from Notch-Induced Kidney Fibrosis Development. J Am Sc Nephrol 2017. doi: 10.1681/ASN.2017020130.
▶︎Functional consequences of the subdomain organization of the sulfs. J Biol Chem 2009. doi: 10.1074/jbc.M109.028472, + QSulf1 remodels the 6-O sulfation states of cell surface heparan sulfate proteoglycans to promote Wnt signaling. J Cell Biol 2003. doi: 10.1083/jcb.200212083)
▶︎Overexpression of integrin-linked kinase promotes lung cancer cell migration and invasion via NF-κB-mediated upregulation of matrix metalloproteinase-9. Int J Mol Sci 2013. doi: 10.7150/ijms.5963. 
▶︎Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice. Aging 2020. doi: 10.18632/aging.103035.
▶︎PM2.5-induced lung injury is attenuated in macrophage-specific NLRP3 deficient mice. Ecotoxicol Envirn Saf 2021. doi: 10.1016/j.eco env.2021.112433.

▶︎Cross-talk between myeloid-derived suppressor cells and macrophages subverts tumor immunity toward a type 2 response. J Immunol 2007. doi:10.4049/jimmunol.179.2.977. 
▶︎Vitamin D/VDR signaling inhibits LPS-induced IFN-gamma and IL-1beta in oral epithelia by regulating hypoxia-inducible factor-1a signaling pathway. Cell Commun Signal 2019. doi: 10.1186/s12964-019-0331-9.
▶︎S100P interacts with integrin alpha7 and increases cancer cell migration and invasion in lung cancer. Oncotarget 2015. doi:10.18632/ oncotarget.4987.
▶︎ATF3 promotes migration and M1/M2 polarization of macrophages by activating tenascin-C via Wnt/beta-catenin pathway. Mole Med Rep 2017. doi: 10.3892/mmr.2017.6992.
▶︎GSK3beta regulates tumor growth and angiogenesis in human glioma cells. Oncotarget 2015. doi:10.18632/oncotarget.5043.
▶︎Suppression of heat shock protein 70 by siRNA enhances the anti-tumor effect of cisplatin in cultured human osteosarcoma cells. Cell Stress Chaperones 2017. doi:10.1007/s12192-017-0793-x.
▶︎PKC-b1 mediates glucose-induced Akt activation and TGF-b1 upregulation in mesangial cells. J An Soc Nephrol 2009. doi: 10.1681/ ASN.2008040445.
▶︎Cyclooxygenase-2 induced beta1-integrin expression in NSCLC and promoted cell invasion via the EP1/MAPK/E2F-1/FoxC2 signal pathway. Scientific Rep 2016. doi: 10.1038/srep33823. 
▶︎COX2/mPGES1/PGE2 pathway regulates PD-L1 expression in tumor-associated macrophages and myeloid-derived suppressor cells. PNAS 2017, 114(5), 1117-1122, doi/10.1073/pnas.1612920114.
▶︎Potential role of senescent macrophages in radiation-induced pulmonary fibrosis. Cell Death Dis 2021, 12(6), 527. doi: 10.1038/ s41419-021-03811-8.
▶︎Integrin alpha-5/beta-6 promotes lung cancer proliferation and metastasis through upregulation of IL-8-mediated MAPK/ERK signaling. Transl Oncol 2018, 11(3), 619-627. doi: 10.1016/j.tranon.2018.02.013. 
▶︎Efficacy of combination therapy with Levatinib and Radioactive iodine in thyroid cancer preclinical model. Int J Mol Sci 2022, 23(17), 9872. doi: 10.3390/ijms23179872.
▶︎Blockade of ERK1/2 by U0126 alleviates uric acid-iinduced EMT and tubular cell injury in rats with hyperuricemic neophro-pathy. Am J Physiol Renal Physiol 2019, 316, 660-673. doi: 10.1152/ajprenal00480.2018.

▶︎Dehydroxymethylepoxyquinomicin, a novel nuclear factor-kB inhibitor, prevents the development of cyclosporine A nephro-toxicity in a rat model. BMC Pharmacol Toxicol 2020, 21(1), 60. doi: 10.1186/s40360-020-00432-3.
▶︎Global Oct4 target gene amalysis reveals novel downstream PTEN and TNC genes required for drug-resistance and metastasis in lung cancer. Nucreic Acids Res 2015, 43(3), 1593-1608. doi: 10.1093/nar/gkv024.
▶︎Notch pathway is activated by MAPK signaling and influences papillary thyroid cancer proliferation. Transl Oncol 2013, 6(2), 197-205. doi: 10.1593/tlo.12442.
▶︎Notch signaling triggered via the ligand DLL4 impedes M2 macrophage differentiation and promotes their apoptosis. Cell Comn Signal 2018, 16(1), 4. doi: 10.1186/s12964-017-0214-x.
▶︎ROS induced epithelial-mesenchymal transition via the TGF-b/PI3K/Akt/mTOR pathway in diabetic nephropathy. Exp Thera-peutic Med 2019, 17, 835-846. doi: 10.3892/etm.2018.7014.
▶︎The Akt-mTORC1 pathway mediates Axl receptor tyrosine kinase-induced mesangial ccell proliferation. J Leukoc Biol 2022, 111(3), 563-571. doi: 10.1002/JLB.2A1220-850RRR.
▶︎M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cell to etoposide. BMC Can-cer 2015, 15, 577. doi: 10.1186/s12885-015-1546-9.
▶︎Tenascin-C modulates cell cycle progression to enhance tumour cell proliferation through AKT/FOXO1 signaling in pancreatic cancer. J Cancer 2018, 9(23), 4449-4462. doi: 10.7150/jca.25926. 

▶︎Diabetes adversely affects macrophages during atherosclerotic plaque regression in mice. Diabetes 2011, 60(6), 1759-1769. doi: 10.2337/db10-0778.
▶︎Tenascin-C increases lung metastasis by impacting blood vessel invasions. Matrix Biol 2019, 83, 26-47. doi: 10.1016/j.matbio. 2019.07.001.