~Activities~

▶︎しばらく Progress Report - B5, B4.
▶︎Cross-talk between myeloid-derived suppressor cells and macrophages subverts tumor immunity toward a type 2 response. J Immunol 2007. doi:10.4049/jimmunol.179.2.977.
▶︎Proteotoxic stress as an exploitable vulnerability in cells with hyperactive AKT. Int J Mol Sci 2021. doi:10.3390/ijms222111376. 
▶︎Vitamin D/VDR signaling inhibits LPS-induced IFN-gamma and IL-1beta in oral epithelia by regulating hypoxia-inducible factor-1a signaling pathway. Cell Commun Signal 2019. doi: 10.1186/s12964-019-0331-9.
▶︎Small molecules SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine type 2 diabetes. Nat Commun 2022. do:10.1038/s41467-022-28435-0.
▶︎Progress Report -B6 → 11/10 卒研発表会
▶︎S100P interacts with integrin alpha7 and increases cancer cell migration and invasion in lung cancer. Oncotarget 2015. doi:10.18632/oncotarget.4987.
▶︎Fenofibrate attenuates fatty acid-induced islet beta-cell dysfunction and apoptosis via inhibiting the NF-kB/MIF dependent inflammatory pathway. Metabolism 2017. doi: 10.1016/j.metabil.2017.09.001.
▶︎Nutrient-dependent regulation of beta-cell proinsulin content. J Biol Chem 2023. doi:10.1016/j.jbc.2023.104836.
▶︎ATF3 promotes migration and M1/M2 polarization of macrophages by activating tenascin-C via Wnt/beta-catenin pathway. Mole Med Rep 2017. doi: 10.3892/mmr.2017.6992.
▶︎GSK3beta regulates tumor growth and angiogenesis in human glioma cells. Oncotarget 2015. doi:10.18632/oncotarget.5043.
▶︎Suppression of heat shock protein 70 by siRNA enhances the anti-tumor effect of cisplatin in cultured human osteosarcoma cells. Cell Stress Chaperones 2017. doi:10.1007/s12192-017-0793-x.
▶︎Pletelet-derived lipids promote insulin secretion of pancreatic beta cells. EMBO Mol Med 2023. doi:10.15252/emmm.2022 1616858.
▶︎PKC-b1 mediates glucose-induced Akt activation and TGF-b1 upregulation in mesangial cells. J An Soc Nephrol 2009. doi: 10.1681/ASN.2008040445.
▶︎Journal club はしばし休会中（Progress Report → 夏季休会）
▶︎XBP1 maintains beta cell identity, represses beta-to-alpha cell transdifferentiation and protects against diabetic beta cell failure during metabolic stress in mice. doi: 10.1007/s00125-022-05669-7.
▶︎Cyclooxygenase-2 induced beta1-integrin expression in NSCLC and promoted cell invasion via the EP1/MAPK/E2F-1/FoxC2 signal pathway. Scientific Rep 2016. doi: 10.1038/srep33823. 
▶︎COX2/mPGES1/PGE2 pathway regulates PD-L1 expression in tumor-associated macrophages and myeloid-derived suppressor cells. PNAS 2017, 114(5), 1117-1122, doi/10.1073/pnas.1612920114.
▶︎Glutamate is an essential mediator in glutamate-amplified insulin secretion. doi. 10.1111/jdi13497.
▶︎Neprilysin inhibition improves intravenous but not oral glucose-mediated insluin secretion via GLP-1R signaling in mice with b-cell dysfunction. doi. 10.1152/ajpendo.00234.2021.
▶︎Potential role of senescent macrophages in radiation-induced pulmonary fibrosis. Cell Death Dis 2021, 12(6), 527. doi: 10.103 8/s41419-021-03811-8.
▶︎Sorafenib and docosahexaenoic acid act in synergy to suppress cancer cell viability: a role of heme oxygenase 1. doi. 10.1186/ s12885-018-4946-9
▶︎The STING-IRF3 pathway is involved in lipotoxic injury of pancreatic b cells in type2 diabetes. doi: 10.1016/j.mce.2020.11890.
▶︎Integrin alpha-5/beta-6 promotes lung cancer proliferation and metastasis through upregulation of IL-8-mediated MAPK/ERK signaling. Transl Oncol 2018, 11(3), 619-627. doi: 10.1016/j.tranon.2018.02.013. 
​▶︎Transcription factor KLF7 promotes osteoclast differentiation by suppressing HO-1. doi. 10.3389/fgene.2022.798433.
▶︎Vitamin D receptor overexpression in b cells ameliorates diabetes in mice. doi. 10.2337/db19-0757.
▶︎Efficacy of combination therapy with Levatinib and Radioactive iodine in thyroid cancer preclinical model. Int J Mol Sci 2022, 23(17), 9872. doi: 10.3390/ijms23179872.
▶︎Blockade of ERK1/2 by U0126 alleviates uric acid-iinduced EMT and tubular cell injury in rats with hyperuricemic neophro-pathy. Am J Physiol Renal Physiol 2019, 316, 660-673. doi: 10.1152/ajprenal00480.2018.
▶︎Biphasic dynamics of beta cell mass in a mouse model of congenital hyperinsulinism: implications for type 2 diabetes. doi. 10.1007/s00125-021-05390-x.
▶︎Dehydroxymethylepoxyquinomicin, a novel nuclear factor-kB inhibitor, prevents the development of cyclosporine A nephro-toxicity in a rat model. BMC Pharmacol Toxicol 2020, 21(1), 60. doi: 10.1186/s40360-020-00432-3.
▶︎Global Oct4 target gene amalysis reveals novel downstream PTEN and TNC genes required for drug-resistance and metastasis in lung cancer. Nucreic Acids Res 2015, 43(3), 1593-1608. doi: 10.1093/nar/gkv024.
▶︎Back1 deficiancy reduces severity of osteoarthritis through upregulation of heme oxygenase-1. doi. 10.1186/s130750-015-0792-1. 
▶︎Imeglimin amplifies glucose-stimulated insulin release from diabetic islets via a distinct mechanism of action. doi. 10.1371/ journal.pone.0241651.
▶︎Pseudoislet aggregation of pancreatic b-cells improves glucose stimulated inslulin secretion by altering glucose metabolism and increasing ATP production. doi. 10.3390/cells11152330.
▶︎Berberine acutely inhibits insulin secretion from b-cells through 3',5'-cyclic adenosine 5'-monophosphate signaling pathway. doi. 10.1210/en.2007-1752.
▶︎Peripheral Ab acts as a negative modulator of insulin secretion. doi. 10.1073/pnas.211772311
▶︎Notch pathway is activated by MAPK signaling and influences papillary thyroid cancer proliferation. Transl Oncol 2013, 6(2), 197-205. doi: 10.1593/tlo.12442.
▶︎Notch signaling triggered via the ligand DLL4 impedes M2 macrophage differentiation and promotes their apoptosis. Cell Comn Signal 2018, 16(1), 4. doi: 10.1186/s12964-017-0214-x.
▶︎ROS induced epithelial-mesenchymal transition via the TGF-b/PI3K/Akt/mTOR pathway in diabetic nephropathy. Exp Thera-peutic Med 2019, 17, 835-846. doi: 10.3892/etm.2018.7014.
▶︎The Akt-mTORC1 pathway mediates Axl receptor tyrosine kinase-induced mesangial ccell proliferation. J Leukoc Biol 2022, 111(3), 563-571. doi: 10.1002/JLB.2A1220-850RRR.
▶︎The possible role of HSF-1 in the negative regulation of HO-1. doi: 10.1016/j.biocel.2004.08.006.
▶︎Induction after administrating Paraquat of heme oxygenase-1 and heat shock protein 70 in the liver of senescence-accelerated mice. doi: 10.1271/bbb.61.1302.
▶︎Modeling human pancreatic beta cell dedifferentiation. doi: 10.1016/j.molmet.2018.02.002.
▶︎M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cell to etoposide. BMC Can-cer 2015, 15, 577. doi: 10.1186/s12885-015-1546-9.
▶︎Tenascin-C modulates cell cycle progression to enhance tumour cell proliferation through AKT/FOXO1 signaling in pancreatic cancer. J Cancer 2018, 9(23), 4449-4462. doi: 10.7150/jca.25926. 
▶︎Keap1/Nrf2 system regulates neuronal survival as revealed through study of keap1 gene-knockout mice. doi: 10.1016/j.bbrc. 2009.01.063.
▶︎miR-330 regulates colorectal cancer oncogenesis by targeting BACH1. doi. 10.34172/apb.2020.054.
▶︎db/db mice exhibit features of human type 2 diabetes that are not present in weight-matched C57BL/6 mice fed a western diet. doi: 10.1155/2017/8503754.
▶︎Heme oxygenase-1 induction by heat shock in rat hepatoma cell line is regulated by the coordinated function of HSF1, NRF2 and BACK1. doi: 10.1093/jb/mvab065.
▶︎Microarray analysis of novel candidate genes responsible for glucose-stimulated insulin secretion in mouse pancreatic bcell line MIN6. doi: 10.1371/journal.pone.0061211.
▶︎NRF2 and HSF1 coordinately regulate heme oxygenase-1 expression. doi: 10.1016/j.bbrc.2018.10.030.
▶︎Chronic glucolipotoxic conditions in pancreatic islets impair insulin secretion due to dysregulated calcium dynamics, glucose responsiveness and mitochondrial activity. doi: 10.1186/1471-2121-14-31.
▶︎Diabetes adversely affects macrophages during atherosclerotic plaque regression in mice. Diabetes 2011, 60(6), 1759-1769. doi: 10.2337/db10-0778.
▶︎Tenascin-C increases lung metastasis by impacting blood vessel invasions. Matrix Biol 2019, 83, 26-47. doi: 10.1016/j.matbio. 2019.07.001.